SCHEMBL20153304

SCHEMBL20153304

Cc1cncc(-n2nccn2)c1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.40
CHRNB4 P30926 3/20 0.40
CHRNA3 P32297 3/20 0.40
CHRNA4 P43681 3/20 0.40
HCAR2 Q8TDS4 1/20 0.36
CYP11B1 P15538 3/20 0.36
CYP11B2 P19099 3/20 0.36
RXRA P19793 1/20 0.36
GRIN1 Q05586 1/20 0.36
GRIN2B Q13224 1/20 0.36
LMNA P02545 1/20 0.33
ATM Q13315 1/20 0.33
CYP2A6 P11509 3/20 0.32
CYP3A4 P08684 1/20 0.32
RIPK2 O43353 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5026594 0.74 KDM4E (0.36) LMNA
SCHEMBL29464651 0.74 CHRNB2 (0.42) CHRNB2CHRNA4
SCHEMBL14909586 0.74 CHRNB2 (0.44) CHRNB2CHRNB4CHRNA3CHRNA4HCAR2
SCHEMBL30782426 0.74 CYP11B2 (0.46) CHRNB4CHRNA3HCAR2CYP11B1CYP11B2
SCHEMBL24921192 0.74 CHRNB2 (0.49) CHRNB2CHRNB4CHRNA3CHRNA4CYP11B1
SCHEMBL21848986 0.74 CYP11B2 (0.38) CYP11B1CYP11B2CYP3A4
SCHEMBL21282987 0.74 FABP4 (0.31)
SCHEMBL15884310 0.72 KDM4E (0.48) CHRNB2CHRNB4CHRNA3CHRNA4RXRA
SCHEMBL20273962 0.71 RXRA (0.43) CHRNB2CHRNB4CHRNA3CHRNA4HCAR2
SCHEMBL21863404 0.70 CHRNB2 (0.40) CHRNB2CHRNB4CHRNA3CHRNA4HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3538525-B1 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2022-06-22 EP disclosed
EP-3538519-B1 INDAZOLE DERIVATIVES AS ALPHA V INTEGRIN ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-07-28 EP disclosed
EP-3538528-B1 PYRROLE AMIDES AS ALPHA V INTEGRIN INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-12-23 EP disclosed
WO-2020065614-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2020-04-02 WO disclosed
WO-2018089353-A1 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed
WO-2018089357-A1 INDAZOLE DERIVATIVES AS αV INTEGRIN ANTAGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed
WO-2018089355-A1 CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed
WO-2018089360-A1 PYRROLE AMIDES AS ALPHA V INTEGRIN INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed