Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.52 |
| ▸ | ITGAV | P06756 | 20/20 | 0.52 |
| ▸ | ITGB6 | P18564 | 7/20 | 0.50 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22600425 | 0.79 | ITGB3 (0.46) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL860659 | 0.76 | ITGB3 (0.56) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL29936679 | 0.75 | ITGB3 (0.55) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL20139335 | 0.75 | ITGB3 (0.55) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL22600427 | 0.75 | ITGB3 (0.51) | ITGB3ITGAVITGB6ITGB5ITGA2B | |
| SCHEMBL23677919 | 0.71 | ITGAV (0.60) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL21784941 | 0.71 | ITGAV (0.54) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL4786884 | 0.71 | ITGB3 (0.71) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL1815095 | 0.69 | ITGAV (0.51) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL20021718 | 0.69 | ITGB3 (0.56) | ITGB3ITGAVITGB6ITGB5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089357-A1 | INDAZOLE DERIVATIVES AS αV INTEGRIN ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |