Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.56 |
| ▸ | ITGAV | P06756 | 20/20 | 0.56 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.52 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.52 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139335 | 0.84 | ITGB3 (0.55) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL29936679 | 0.84 | ITGB3 (0.55) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL20153798 | 0.76 | ITGB3 (0.52) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL2489899 | 0.75 | LTA4H (0.47) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL21784941 | 0.73 | ITGAV (0.54) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL20141059 | 0.72 | ITGB3 (0.62) | ITGB3ITGAVITGB5 | |
| SCHEMBL2490589 | 0.72 | ITGB3 (1.00) | ITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL20139327 | 0.72 | ITGB3 (0.74) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL20021718 | 0.71 | ITGB3 (0.56) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL29988582 | 0.71 | ITGB3 (0.61) | ITGB3ITGAVITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425010-B8 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICALS INC (US) | 2012-03-28 | — | — | EP | disclosed |