SCHEMBL20155133

SCHEMBL20155133

Cn1nc2c(Br)cn(C)c(=O)c2n1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.37
TOP2A P11388 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21224338 0.76 BRD4 (0.36)
SCHEMBL20155003 0.74 BRD4 (0.36) ADORA2A
SCHEMBL20155066 0.73 MAT2A (0.34) ADORA2A
SCHEMBL20155332 0.69 ADORA2A (0.36) ADORA2A
SCHEMBL20154966 0.69 BRD4 (0.35)
SCHEMBL20155118 0.69 NPC1 (0.40)
SCHEMBL20154927 0.68 MAT2A (0.40)
SCHEMBL20155093 0.68 MAT2A (0.36) ADORA2A
SCHEMBL20155436 0.67 TLR8 (0.41)
SCHEMBL16651917 0.67 BRD4 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018086604-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF 山东罗欣药业集团股份有限公司 2018-05-17 WO disclosed