Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 3/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.42 |
| ▸ | TUBB | P07437 | 5/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27895629 | 0.84 | SMN1; SMN2 (0.52) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL24026461 | 0.83 | TUBB4A (0.40) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL20155668 | 0.80 | TUBB4A (0.40) | CTSATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL24288066 | 0.80 | TUBB4A (0.40) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL20150113 | 0.80 | TUBB4A (0.38) | CTSATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29377827 | 0.80 | BRD4 (0.43) | BRD4NPC1RAB9ASMN1; SMN2LTA4H | |
| SCHEMBL9510722 | 0.80 | BRD4 (0.43) | BRD4NPC1RAB9ASMN1; SMN2LTA4H | |
| SCHEMBL3031254 | 0.79 | RAB9A (0.53) | BRD4NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9507232 | 0.77 | BRD4 (0.41) | BRD4NPC1RAB9ASMN1; SMN2LTA4H | |
| SCHEMBL31546532 | 0.77 | NOS3 (0.41) | BRD4NPC1RAB9ASMN1; SMN2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220508-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2022-01-11 | — | — | US | disclosed |
| US-11174265-B2 | — | — | 2021-11-16 | — | — | US | disclosed |
| US-20210094948-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-04-01 | — | — | US | disclosed |
| US-10647713-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11220508-B2 | TYK2 inhibitors and uses thereof | TYK2, JAK2, JAK1 | CTSA 4108/4885TUBB4A 2425/4885TUBB 1669/4885 |
| US-20210094948-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | CTSA 4108/4885TUBB4A 2425/4885TUBB 1669/4885 |
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | CTSA 4108/4885TUBB4A 2425/4885TUBB 1669/4885 |
| US-11174265-B2 | — | TYK2, JAK2, JAK1 | CTSA 3218/4885TUBB4A 1544/4885TUBB 844/4885 |
| US-10647713-B2 | TYK2 inhibitors and uses thereof | TYK2, JAK2, JAK1 | CTSA 4108/4885TUBB4A 2425/4885TUBB 1669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.