Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.66 |
| ▸ | MMP9 | P14780 | 2/20 | 0.66 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27405504 | 0.86 | MMP2 (0.63) | MMP2MMP9FKBP1ASMN1; SMN2LMNA | |
| SCHEMBL21281608 | 0.86 | MMP2 (0.63) | MMP2MMP9FKBP1ASMN1; SMN2LMNA | |
| SCHEMBL27405503 | 0.86 | MMP2 (0.63) | MMP2MMP9FKBP1ASMN1; SMN2LMNA | |
| SCHEMBL2709244 | 0.84 | BRD4 (0.71) | MMP2MMP9FKBP1ASMN1; SMN2LMNA | |
| SCHEMBL23519421 | 0.83 | ALDH1A1 (0.65) | MMP2MMP9FKBP1ASMN1; SMN2LMNA | |
| SCHEMBL6996 | 0.83 | ALDH1A1 (0.65) | MMP2MMP9FKBP1ASMN1; SMN2LMNA | |
| SCHEMBL6997 | 0.83 | ALDH1A1 (0.65) | MMP2MMP9FKBP1ASMN1; SMN2LMNA | |
| SCHEMBL695760 | 0.83 | MMP2 (0.64) | MMP2MMP9FKBP1ASMN1; SMN2LMNA | |
| SCHEMBL3904609 | 0.83 | MMP2 (0.64) | MMP2MMP9FKBP1ASMN1; SMN2LMNA | |
| SCHEMBL31086821 | 0.83 | MMP2 (0.78) | MMP2MMP9FKBP1ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538527-B1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2018089358-A1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |