Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 16/20 | 0.54 |
| ▸ | ARG2 | P78540 | 16/20 | 0.54 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894569 | 0.91 | ARG1 (0.68) | ARG1ARG2 | |
| SCHEMBL30169834 | 0.91 | ARG1 (0.68) | ARG1ARG2 | |
| SCHEMBL10265453 | 0.82 | ARG1 (0.63) | ARG1ARG2 | |
| SCHEMBL20156683 | 0.80 | ARG1 (0.57) | ARG1ARG2HTR2A | |
| SCHEMBL12292594 | 0.80 | ARG1 (0.81) | ARG1ARG2 | |
| SCHEMBL20683512 | 0.80 | ARG1 (0.53) | ARG1ARG2HTR2A | |
| SCHEMBL18323839 | 0.78 | ARG1 (0.38) | ARG1ARG2 | |
| SCHEMBL20683540 | 0.77 | ARG1 (0.81) | ARG1ARG2 | |
| SCHEMBL20683404 | 0.77 | ARG1 (0.61) | ARG1ARG2HTR2A | |
| SCHEMBL20485919 | 0.77 | ARG1 (0.72) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |