Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 9/20 | 0.57 |
| ▸ | ARG2 | P78540 | 9/20 | 0.57 |
| ▸ | HTR2A | P28223 | 8/20 | 0.43 |
| ▸ | HTR2C | P28335 | 8/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894204 | 0.90 | ARG1 (0.71) | ARG1ARG2 | |
| SCHEMBL30169941 | 0.90 | ARG1 (0.71) | ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL895812 | 0.89 | ARG1 (0.70) | ARG1ARG2 | |
| SCHEMBL12292594 | 0.82 | ARG1 (0.81) | ARG1ARG2 | |
| SCHEMBL20156684 | 0.80 | ARG1 (0.54) | ARG1ARG2HTR2A | |
| SCHEMBL10265453 | 0.80 | ARG1 (0.63) | ARG1ARG2KCNH2 | |
| SCHEMBL20683512 | 0.80 | ARG1 (0.53) | ARG1ARG2HTR2AHTR2C | |
| SCHEMBL20683540 | 0.77 | ARG1 (0.81) | ARG1ARG2 | |
| SCHEMBL20683404 | 0.77 | ARG1 (0.61) | ARG1ARG2HTR2AOPRM1 | |
| SCHEMBL20683407 | 0.76 | ARG1 (0.60) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |