Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157254 | 0.97 | DRD2 (0.52) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL20157058 | 0.91 | DRD4 (0.43) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL20157265 | 0.80 | RET (0.40) | DRD2DRD4PARP1TNK1 | |
| SCHEMBL20140323 | 0.78 | KDM4E (0.54) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL20157139 | 0.78 | DRD2 (0.50) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL20156994 | 0.78 | KDM4E (0.54) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL20140016 | 0.78 | HSD11B1 (0.55) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL20142471 | 0.76 | DRD2 (0.42) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL20142472 | 0.76 | DRD2 (0.42) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL20140731 | 0.76 | DRD4 (0.54) | DRD2HTR2AHTR1AHTR7DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |