Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 14/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157058 | 0.84 | DRD4 (0.43) | DRD4DRD2DRD3 | |
| SCHEMBL20157254 | 0.82 | DRD2 (0.52) | DRD4DRD2DRD3PARP1TNK1 | |
| SCHEMBL20156964 | 0.82 | MTOR (0.49) | RETDRD4DRD2DRD3PPARG | |
| SCHEMBL20141897 | 0.82 | HTT (0.47) | RETPPARGPARP1PARP2TNK1 | |
| SCHEMBL20139878 | 0.80 | PRKAA2 (0.43) | RETPPARG | |
| SCHEMBL20156837 | 0.80 | DRD2 (0.49) | DRD4DRD2PARP1TNK1 | |
| SCHEMBL20141707 | 0.79 | MTOR (0.47) | PPARGPARP1 | |
| SCHEMBL20140046 | 0.76 | MTOR (0.47) | PPARGPARP1PARP2 | |
| SCHEMBL20140070 | 0.76 | MTOR (0.47) | PPARGPARP1PARP2 | |
| SCHEMBL20140048 | 0.76 | MTOR (0.47) | PPARGPARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |