Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 8/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015754 | 1.00 | HTT (0.44) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL2013942 | 0.86 | HTT (0.45) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL2014980 | 0.85 | SLC40A1 (0.38) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL2014977 | 0.85 | SLC40A1 (0.38) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL2016501 | 0.81 | KHK (0.36) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL2017050 | 0.81 | SLC40A1 (0.40) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL2016811 | 0.81 | METAP2 (0.34) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL2013515 | 0.80 | SLC40A1 (0.36) | HTTLMNASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL2014591 | 0.78 | METAP2 (0.44) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL2014589 | 0.78 | METAP2 (0.44) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |