Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 3/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20758895 | 0.84 | LMNA (0.49) | TSHRLMNACA1CA12DNM1 | |
| SCHEMBL5366870 | 0.81 | KMT2A (0.53) | KDM5AMEN1KMT2ATSHRLMNA | |
| SCHEMBL11585151 | 0.78 | DNM1 (0.41) | KDM5AMEN1KMT2ALMNADNM1 | |
| SCHEMBL25649107 | 0.76 | MEN1 (0.35) | MEN1KMT2ATSHR | |
| SCHEMBL27487019 | 0.75 | KDM5A (0.49) | KDM5APOLBPOLA1MEN1KMT2A | |
| SCHEMBL5595623 | 0.75 | KDM5A (0.49) | KDM5APOLBPOLA1MEN1KMT2A | |
| SCHEMBL9774513 | 0.74 | CHRNB2 (0.42) | MEN1KMT2ATSHRMAPT | |
| SCHEMBL13165157 | 0.74 | CA1 (0.44) | KDM5ACA1CA2CA12DNM1 | |
| SCHEMBL15835848 | 0.73 | MGAM (0.40) | TSHRLMNACA1CA2CA12 | |
| SCHEMBL11585199 | 0.73 | GPR84 (0.47) | KDM5AMEN1KMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086593-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE | 礼沃（上海）医药科技有限公司 | 2018-05-17 | — | — | WO | disclosed |