SCHEMBL20157772

SCHEMBL20157772

Cc1ccc(C(=O)c2ccc(CBr)cc2Br)c(F)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.38
CYP4F2 P78329 1/20 0.37
CYP4A11 Q02928 1/20 0.37
MAPT P10636 2/20 0.35
MAPK1 P28482 2/20 0.35
NPC1 O15118 1/20 0.35
HTT P42858 1/20 0.35
NPSR1 Q6W5P4 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
TP53 P04637 1/20 0.34
ALOX15 P16050 1/20 0.34
TSHR P16473 1/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.34
DGAT1 O75907 1/20 0.34
THRB P10828 2/20 0.34
KMT2A Q03164 1/20 0.34
THRA P10827 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20157893 0.86 NPC1 (0.41) LOXL2MAPTMAPK1NPC1HTT
SCHEMBL21564879 0.86 CYP4F2 (0.37) LOXL2CYP4F2CYP4A11NPSR1CYP1A2
SCHEMBL20157777 0.85 CES2 (0.47) HTTDGAT1KMT2ANR3C1
SCHEMBL20157821 0.83 CYP4F2 (0.46) CYP4F2CYP4A11MAPTNPC1TP53
SCHEMBL20157332 0.83 NPC1 (0.40) CYP4F2CYP4A11NPC1NPSR1CYP1A2
SCHEMBL20158071 0.83 KMT2A (0.36) LOXL2MAPTMAPK1NPC1HTT
SCHEMBL20157960 0.81 SRD5A2 (0.49) CYP4F2CYP4A11MAPTMAPK1NPC1
SCHEMBL20158023 0.81 ABL1 (0.45) CYP4F2CYP4A11MAPTNPC1HTT
SCHEMBL9726681 0.79 CSNK2A1 (0.47) LOXL2MAPTMAPK1NPC1HTT
SCHEMBL7577366 0.79 CSNK2A1 (0.43) CYP4F2CYP4A11MAPTTSHRTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3539960-A1 NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) 2019-09-18 EP disclosed
WO-2018086605-A1 NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF 山东罗欣药业集团股份有限公司 2018-05-17 WO disclosed