SCHEMBL20157951

SCHEMBL20157951

Cc1ccc(C(=O)c2ccc(CS(C)(=O)=O)cc2Br)cc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.47
SRD5A2 P31213 1/20 0.44
HTT P42858 2/20 0.43
NPC1 O15118 1/20 0.43
MAPK1 P28482 1/20 0.43
ALDH1A1 P00352 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
GAA P10253 1/20 0.41
LMNA P02545 2/20 0.41
CA2 P00918 1/20 0.39
AKR1C3 P42330 1/20 0.39
KDM5A P29375 1/20 0.39
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
PTPN1 P18031 1/20 0.38
RXRA P19793 1/20 0.37
C5AR1 P21730 1/20 0.37
CES2 O00748 1/20 0.37
CES1 P23141 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20157557 0.88 PTPN1 (0.39) MAPTHTTALDH1A1GAALMNA
SCHEMBL20157342 0.88 SRD5A2 (0.43) MAPTSRD5A2HTTNPC1MAPK1
SCHEMBL20157973 0.86 SRD5A2 (0.42) MAPTSRD5A2HTTNPC1MAPK1
SCHEMBL20158005 0.83 HPGD (0.39) MAPTHTTNPC1MAPK1ALDH1A1
SCHEMBL20157960 0.82 SRD5A2 (0.49) MAPTSRD5A2HTTNPC1MAPK1
SCHEMBL20157469 0.81 POLB (0.47) MAPTSRD5A2HTTNPC1MAPK1
SCHEMBL20157976 0.80 MAPT (0.49) MAPTSRD5A2HTTNPC1MAPK1
SCHEMBL21362472 0.77 SRD5A2 (0.43) MAPTSRD5A2HTTNPC1MAPK1
SCHEMBL20157579 0.76 TP53 (0.38) MAPTHTTMAPK1ALDH1A1GAA
SCHEMBL20157815 0.76 KMT2A (0.40) MAPTSRD5A2NPC1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018086605-A1 NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF 山东罗欣药业集团股份有限公司 2018-05-17 WO disclosed