Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158040 | 0.85 | ACHE (0.54) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL21362429 | 0.81 | SMN1; SMN2 (0.41) | RAB9AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL29442867 | 0.76 | HTT (0.50) | HTTLMNAMAPK1RAB9AALDH1A1 | |
| SCHEMBL186570 | 0.76 | HTT (0.50) | HTTLMNAMAPK1RAB9AALDH1A1 | |
| SCHEMBL20157608 | 0.75 | ALDH1A1 (0.44) | ACHEALDH1A1TAS2R14 | |
| SCHEMBL21362819 | 0.74 | ACHE (0.40) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL991185 | 0.72 | HTT (0.56) | HTTLMNAMAPK1RAB9AACHE | |
| SCHEMBL20157984 | 0.72 | NPC1 (0.38) | HTTLMNARAB9AACHEMEP1B | |
| SCHEMBL29463290 | 0.71 | MAPT (0.56) | HTTMAPK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL333582 | 0.71 | MAPT (0.56) | HTTMAPK1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086605-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |