Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157512 | 0.85 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20158037 | 0.81 | HTT (0.43) | RAB9AKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL20157513 | 0.75 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20157850 | 0.71 | MAPT (0.39) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL21252887 | 0.71 | NPC1 (0.42) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL29463290 | 0.70 | MAPT (0.56) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL333582 | 0.70 | MAPT (0.56) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL20158023 | 0.70 | ABL1 (0.45) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL5286155 | 0.70 | NPC1 (0.42) | SMN1; SMN2NPC1RAB9AALDH1A1FFAR4 | |
| SCHEMBL20158025 | 0.70 | NPC1 (0.42) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |