Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.71 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.71 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159229 | 0.88 | MTOR (0.74) | MTORRPTORMLST8ALDH1A1MEN1 | |
| SCHEMBL20158895 | 0.83 | MTOR (1.00) | MTORRPTORMLST8ALDH1A1MEN1 | |
| SCHEMBL20140071 | 0.79 | MTOR (0.78) | MTORRPTORMLST8ALDH1A1MEN1 | |
| SCHEMBL20159216 | 0.79 | MTOR (0.81) | MTORRPTORMLST8ALDH1A1MEN1 | |
| SCHEMBL20141504 | 0.78 | MTOR (0.67) | MTORRPTORMLST8ALDH1A1HTR7 | |
| SCHEMBL20159090 | 0.78 | MTOR (0.71) | MTORRPTORMLST8ALDH1A1HTR7 | |
| SCHEMBL20159112 | 0.77 | MTOR (0.58) | MTORRPTORMLST8ALDH1A1MAPT | |
| SCHEMBL20140865 | 0.77 | MTOR (0.48) | MTORRPTORMLST8ALDH1A1LMNA | |
| SCHEMBL20158993 | 0.77 | MTOR (0.64) | MTORRPTORMLST8ALDH1A1MEN1 | |
| SCHEMBL20159093 | 0.77 | MTOR (0.68) | MTORRPTORMLST8ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |