Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.74 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.74 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159226 | 0.88 | MTOR (0.71) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20159155 | 0.86 | MTOR (0.65) | MTORRPTORMLST8NPC1ALDH1A1 | |
| SCHEMBL20158895 | 0.85 | MTOR (1.00) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20159090 | 0.80 | MTOR (0.71) | MTORRPTORMLST8RAB9AALDH1A1 | |
| SCHEMBL20141569 | 0.79 | RAB9A (0.46) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20158993 | 0.79 | MTOR (0.64) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20159230 | 0.78 | MTOR (0.65) | MTORRPTORMLST8ALDH1A1LMNA | |
| SCHEMBL20159227 | 0.77 | MTOR (1.00) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20140071 | 0.77 | MTOR (0.78) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20158919 | 0.77 | MTOR (0.72) | MTORRPTORMLST8ALDH1A1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |