Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 3/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24671755 | 0.84 | HTT (0.44) | HTTLMNAGNAI3GNAO1GNAI1 | |
| SCHEMBL21569670 | 0.84 | HPGD (0.38) | HTTFASNALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL25512071 | 0.81 | HTT (0.41) | HTTLMNAFASNGNAI3GNAO1 | |
| SCHEMBL12258956 | 0.80 | HPGD (0.50) | HTTLMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL13621127 | 0.78 | HTT (0.44) | HTTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL90793 | 0.77 | NCF1 (0.44) | LMNAGNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL20715643 | 0.77 | NCF1 (0.44) | LMNAGNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL23841452 | 0.77 | NCF1 (0.44) | LMNAGNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL12258964 | 0.77 | ALDH1A1 (0.52) | HTTLMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL21569732 | 0.76 | NR1D1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089695-A1 | TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |