Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26790983 | 0.90 | HPGD (0.45) | HTTALDH1A1SMN1; SMN2DPP8DPP7 | |
| SCHEMBL22874706 | 0.85 | SMN1; SMN2 (0.46) | HTTLMNAGNAI3GNAO1GNAI1 | |
| SCHEMBL17715716 | 0.85 | HSD11B1 (0.56) | LMNAALDH1A1SMN1; SMN2HSD11B1 | |
| SCHEMBL25512071 | 0.84 | HTT (0.41) | HTTLMNAGNAI3GNAO1GNAI1 | |
| SCHEMBL20159571 | 0.84 | HTT (0.45) | HTTLMNAGNAI3GNAO1GNAI1 | |
| SCHEMBL25489003 | 0.83 | HRH3 (0.54) | ALDH1A1SMN1; SMN2DPP8DPP7HSD11B1 | |
| SCHEMBL26263853 | 0.81 | SMN1; SMN2 (0.57) | HTTLMNAGNAI3GNAO1GNAI1 | |
| SCHEMBL24334511 | 0.81 | SMN1; SMN2 (0.57) | HTTLMNAGNAI3GNAO1GNAI1 | |
| SCHEMBL27263531 | 0.80 | GNAI3 (0.52) | HTTLMNAGNAI3GNAO1GNAI1 | |
| SCHEMBL19176806 | 0.79 | HPGD (0.52) | HTTLMNAALDH1A1SMN1; SMN2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |