Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19884757 | 0.90 | LMNA (0.61) | LMNAMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL2077746 | 0.87 | TSHR (0.65) | LMNAMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL20160117 | 0.85 | HTT (0.57) | LMNAMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL8191261 | 0.85 | L3MBTL3 (0.57) | LMNAMEN1KMT2ASMN1; SMN2L3MBTL3 | |
| SCHEMBL24204687 | 0.85 | HTT (0.56) | LMNATSHRHRH3L3MBTL3L3MBTL1 | |
| SCHEMBL24371474 | 0.84 | LMNA (0.59) | LMNAMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL21569638 | 0.84 | LMNA (0.60) | LMNAMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL19203828 | 0.82 | HTT (0.61) | LMNATSHRHRH3L3MBTL3L3MBTL1 | |
| SCHEMBL15219332 | 0.82 | HTT (0.61) | LMNATSHRHRH3L3MBTL3L3MBTL1 | |
| SCHEMBL1371577 | 0.81 | SMN1; SMN2 (0.48) | LMNASMN1; SMN2HRH3L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089695-A1 | TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |