Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.44 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.44 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191261 | 0.97 | L3MBTL3 (0.57) | HTTLMNAL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL24204687 | 0.89 | HTT (0.56) | HTTLMNAL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL24352372 | 0.86 | LMNA (0.60) | HTTLMNAL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL19203828 | 0.86 | HTT (0.61) | HTTLMNAL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL15219332 | 0.86 | HTT (0.61) | HTTLMNAL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL20160121 | 0.85 | LMNA (0.64) | HTTLMNAL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL14155726 | 0.85 | HTT (0.75) | HTTLMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL24334506 | 0.83 | HSD11B1 (0.56) | HTTLMNAL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL24206985 | 0.82 | HTT (0.49) | HTTLMNAL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL21569648 | 0.82 | LMNA (0.47) | HTTLMNAL3MBTL3L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089695-A1 | TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |