Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | UBE2M | P61081 | 4/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23449305 | 0.79 | PIK3CD (0.48) | PARP1KDM4EGPR183HRH3TSHR | |
| SCHEMBL20070338 | 0.78 | CHRM1 (0.44) | ROCK2CYP3A4CHRM1HRH3 | |
| SCHEMBL19630484 | 0.75 | KDM4E (0.38) | PARP1KDM4EUBE2MDCUN1D1TSHR | |
| SCHEMBL11573468 | 0.75 | — | — | |
| SCHEMBL20154460 | 0.75 | ROCK2 (0.38) | ROCK2CYP3A4CHRM1MMP13MMP1 | |
| SCHEMBL22812221 | 0.75 | CHRM1 (0.50) | KDM4ECHRM1TSHRMCL1 | |
| SCHEMBL18389800 | 0.72 | CYP1A2 (0.48) | ROCK2CYP3A4KDM4ECHRM1CHRM3 | |
| SCHEMBL20926962 | 0.72 | KDM4E (0.40) | PARP1KDM4EHRH3UBE2MDCUN1D1 | |
| SCHEMBL8488963 | 0.72 | MMP1 (0.46) | ROCK2CYP3A4MMP1MMP2MMP8 | |
| SCHEMBL18713080 | 0.71 | NAMPT (0.45) | PARP1KDM4EHRH3UBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134702-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134702-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | ROCK2 581/4885CYP3A4 3158/4885PARP1 2894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.