Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18390264 | 0.83 | CHRM1 (0.65) | CHRM1ALDH1A1KMT2AMEN1 | |
| SCHEMBL20353685 | 0.80 | CHRM1 (0.51) | CHRM1KDM4ETSHRALDH1A1KMT2A | |
| SCHEMBL4874415 | 0.77 | CES2 (0.50) | CHRM1KDM4ETSHRALDH1A1GAA | |
| SCHEMBL29522101 | 0.76 | CHRM1 (0.63) | CHRM1TSHRGAA | |
| SCHEMBL18390258 | 0.76 | CHRM1 (0.63) | CHRM1TSHRGAA | |
| SCHEMBL20160374 | 0.75 | ROCK2 (0.35) | CHRM1KDM4ETSHRMCL1 | |
| SCHEMBL23449305 | 0.71 | PIK3CD (0.48) | KDM4ETSHRALDH1A1KMT2AMCL1 | |
| SCHEMBL9910968 | 0.71 | KCNQ2 (0.56) | CHRM1KDM4ETSHRALDH1A1GAA | |
| SCHEMBL13149986 | 0.70 | GAA (0.66) | CHRM1KDM4ETSHRALDH1A1GAA | |
| SCHEMBL14359456 | 0.70 | LMNA (0.47) | CHRM1ALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |