Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.50 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.50 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10114040 | 0.83 | CYP1A2 (0.66) | GAATSHRALDH1A1KMT2AHTT | |
| SCHEMBL20161760 | 0.76 | TRPA1 (0.48) | TSHRALDH1A1CYP1A2MAPK1 | |
| SCHEMBL15717788 | 0.73 | NTRK1 (0.85) | NTRK1GAATSHRKCNJ6KCNJ5 | |
| SCHEMBL16595134 | 0.72 | NTRK1 (1.00) | NTRK1GAATSHRKCNJ6KCNJ5 | |
| SCHEMBL684090 | 0.71 | ADORA2B (0.54) | TSHRALDH1A1L3MBTL1KMT2ACYP1A2 | |
| SCHEMBL14754417 | 0.71 | CYP1A2 (0.60) | TSHRALDH1A1KMT2AHTTCYP1A2 | |
| SCHEMBL25793172 | 0.71 | NTRK1 (0.80) | NTRK1GAATSHRKCNJ6KCNJ5 | |
| SCHEMBL7020240 | 0.70 | ADORA2B (0.62) | ALDH1A1KMT2AMEN1LMNAMAPK1 | |
| SCHEMBL13975495 | 0.70 | NTRK1 (0.78) | NTRK1GAATSHRKCNJ6KCNJ5 | |
| SCHEMBL515911 | 0.69 | ADORA2B (0.61) | TSHRALDH1A1L3MBTL1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | ELI LILLY AND COMPANY | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | TRPA1, TRPV1, TRPV3 | NTRK1 2627/4885GAA 640/4885TSHR 3225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.