Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | MC3R | P41968 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10114018 | 0.81 | TRPA1 (0.74) | TRPA1RXFP1TP53CYP1A2SMN1; SMN2 | |
| SCHEMBL20161622 | 0.76 | NTRK1 (0.54) | CYP1A2ALDH1A1MAPK1TSHR | |
| SCHEMBL684090 | 0.76 | ADORA2B (0.54) | RXFP1CYP1A2ADORA2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL4533692 | 0.75 | RXFP1 (0.78) | TRPA1RXFP1TP53CYP1A2SMN1; SMN2 | |
| SCHEMBL7020240 | 0.75 | ADORA2B (0.62) | RXFP1ADORA2BSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL10114217 | 0.74 | PORCN (0.70) | TRPA1RXFP1CYP1A2ADORA2BSMN1; SMN2 | |
| SCHEMBL11702678 | 0.74 | ADORA2B (0.64) | RXFP1ADORA2BSMN1; SMN2MAPK1PIK3CD | |
| SCHEMBL20161768 | 0.73 | MAOB (0.49) | RXFP1TP53CYP1A2ADORA2BSMN1; SMN2 | |
| SCHEMBL5471122 | 0.72 | ADORA2B (0.62) | RXFP1ADORA2BSMN1; SMN2MAPK1PIK3CD | |
| SCHEMBL10114180 | 0.72 | PORCN (0.76) | TRPA1RXFP1TP53CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | ELI LILLY AND COMPANY | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | TRPA1, TRPV1, TRPV3 | TRPA1 1/4885RXFP1 1374/4885TP53 4574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.