Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2550700 | 0.80 | SLC40A1 (0.39) | HSP90AA1KDM4ENAPRTHCAR2SLC40A1 | |
| SCHEMBL22001834 | 0.80 | HSP90AA1 (0.37) | HSP90AA1KDM4ENAPRTHCAR2SLC40A1 | |
| Hydrazine SCHEMBL27587071 | 0.77 | HSP90AA1 (0.39) | HSP90AA1KDM4ENAPRTHCAR2SLC40A1 | |
| SCHEMBL7835984 | 0.74 | SLC40A1 (0.41) | HSP90AA1KDM4ENAPRTHCAR2SLC40A1 | |
| SCHEMBL329658 | 0.72 | SLC40A1 (0.40) | HSP90AA1KDM4ENAPRTHCAR2SLC40A1 | |
| SCHEMBL12655512 | 0.72 | HSP90AA1 (0.39) | HSP90AA1KDM4ENAPRTHCAR2SLC40A1 | |
| SCHEMBL12622251 | 0.70 | KDM4E (0.47) | HSP90AA1KDM4ENAPRTHCAR2SLC40A1 | |
| SCHEMBL27967561 | 0.70 | SLC40A1 (0.46) | HSP90AA1KDM4ENAPRTHCAR2SLC40A1 | |
| SCHEMBL29497597 | 0.70 | SLC40A1 (0.46) | HSP90AA1KDM4ENAPRTHCAR2SLC40A1 | |
| SCHEMBL1076499 | 0.70 | CA12 (0.43) | HSP90AA1KDM4ENAPRTHCAR2SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | ELI LILLY AND COMPANY | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133170-A1 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS | TRPA1, TRPV1, TRPV3 | HSP90AA1 532/4885KDM4E 4704/4885NAPRT 2342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.