Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KHK | P50053 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703246 | 0.78 | MAPT (0.41) | FLT3JAK2JAK1JAK3TYK2 | |
| Hydrochloric Acid SCHEMBL23704668 | 0.76 | MAPT (0.44) | FLT3JAK2JAK1JAK3TYK2 | |
| SCHEMBL12093594 | 0.76 | LMNA (0.39) | FLT3JAK2JAK1JAK3TYK2 | |
| SCHEMBL5199006 | 0.74 | JAK2 (0.35) | FLT3JAK2JAK1JAK3TYK2 | |
| SCHEMBL553466 | 0.74 | ALDH1A1 (0.41) | JAK2JAK1JAK3TYK2ALOX5AP | |
| SCHEMBL20257886 | 0.74 | JAK2 (0.35) | FLT3JAK2JAK1JAK3TYK2 | |
| SCHEMBL12090072 | 0.73 | TGFBR1 (0.41) | FLT3JAK2JAK1JAK3TYK2 | |
| SCHEMBL10263497 | 0.73 | TLR7 (0.39) | FLT3JAK2JAK1JAK3TYK2 | |
| SCHEMBL20921989 | 0.71 | TAS2R8 (0.44) | JAK2JAK1JAK3TGFBR1MAP4K4 | |
| SCHEMBL10203201 | 0.71 | TGFBR1 (0.40) | FLT3JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089261-A2 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |