Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13158753 | 0.97 | — | — | |
| SCHEMBL14216651 | 0.80 | BBOX1 (0.52) | CYP3A4SLC5A7MEN1LMNAKMT2A | |
| SCHEMBL12790568 | 0.77 | BBOX1 (0.46) | BBOX1 | |
| Hydrochloric Acid SCHEMBL7169805 | 0.73 | CYP3A4 (0.45) | CYP3A4SLC5A7MEN1LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL28528581 | 0.73 | SLC22A1 (0.44) | BBOX1DNM1TSHR | |
| SCHEMBL4788386 | 0.72 | MEN1 (0.39) | CYP3A4SLC5A7MEN1LMNAKMT2A | |
| SCHEMBL12790559 | 0.71 | BBOX1 (0.54) | MEN1LMNAKMT2ABBOX1TSHR | |
| SCHEMBL7592349 | 0.71 | — | — | |
| SCHEMBL12790560 | 0.71 | MEN1 (0.43) | CYP3A4SLC5A7MEN1LMNAKMT2A | |
| SCHEMBL22034530 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11135150-B2 | Compositions and methods for improving the quality of chemically treated hair | L'OREAL (FR) | 2021-10-05 | — | — | US | disclosed |
| US-20180140531-A1 | COMPOSITIONS AND METHODS FOR IMPROVING THE QUALITY OF CHEMICALLY TREATED HAIR | L'OREAL (FR) | 2018-05-24 | — | — | US | disclosed |
| US-20180140532-A1 | COMPOSITIONS AND METHODS FOR RESTRUCTURING CHEMICALLY TREATED HAIR | L'OREAL (FR) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180140532-A1 | COMPOSITIONS AND METHODS FOR RESTRUCTURING CHEMICALLY TREATED HAIR | TET3, TYR, DDC | CYP3A4 3229/4885SLC5A7 3571/4885MEN1 2556/4885 |
| US-11135150-B2 | Compositions and methods for improving the quality of chemically treated hair | SRM, TET2, TET3 | CYP3A4 4443/4885SLC5A7 2234/4885MEN1 1922/4885 |
| US-20180140531-A1 | COMPOSITIONS AND METHODS FOR IMPROVING THE QUALITY OF CHEMICALLY TREATED HAIR | SRM, TET2, TET3 | CYP3A4 4443/4885SLC5A7 2234/4885MEN1 1922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.