Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SCNN1A | P37088 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015349 | 0.88 | HTT (0.57) | TP53SMN1; SMN2POLBLMNAMEN1 | |
| SCHEMBL2052007 | 0.87 | MAPT (0.57) | TP53MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL2018696 | 0.87 | MEN1 (0.65) | TP53MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL2014088 | 0.87 | LMNA (0.65) | TP53SMN1; SMN2POLBLMNAMEN1 | |
| SCHEMBL2018182 | 0.85 | MEN1 (0.52) | TP53SMN1; SMN2POLBLMNAMEN1 | |
| SCHEMBL20209486 | 0.84 | MAPT (0.52) | TP53MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL29625044 | 0.84 | MAPT (0.52) | TP53MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL2018051 | 0.83 | TP53 (0.45) | TP53MAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL2016076 | 0.83 | MEN1 (0.50) | TP53SMN1; SMN2POLBLMNAMEN1 | |
| SCHEMBL12636316 | 0.80 | SCNN1A (0.45) | MAPTSMN1; SMN2LMNASCNN1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |