Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2051417 | 0.88 | TP53 (0.44) | TP53PRKACARPS6KB1GSK3BROCK1 | |
| SCHEMBL2015349 | 0.84 | HTT (0.57) | TP53LMNAMEN1KMT2AHTT | |
| SCHEMBL2016412 | 0.83 | TP53 (0.56) | TP53LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2014088 | 0.82 | LMNA (0.65) | TP53LMNAMEN1KMT2AHTT | |
| SCHEMBL2018696 | 0.82 | MEN1 (0.65) | TP53LMNAMEN1KMT2AHTT | |
| SCHEMBL2014575 | 0.82 | CTSA (0.38) | PRKACARPS6KB1GSK3BROCK1LMNA | |
| Iodide SCHEMBL2016400 | 0.81 | CTSA (0.37) | PRKACARPS6KB1GSK3BROCK1LMNA | |
| SCHEMBL2018182 | 0.81 | MEN1 (0.52) | TP53LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL2016076 | 0.79 | MEN1 (0.50) | TP53LMNAMEN1KMT2AHTT | |
| SCHEMBL16407623 | 0.76 | BRD4 (0.48) | LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |