Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018182 | 0.90 | MEN1 (0.52) | MEN1KMT2ATP53HPGDALDH1A1 | |
| SCHEMBL2018696 | 0.88 | MEN1 (0.65) | MEN1KMT2ATP53HPGDALDH1A1 | |
| SCHEMBL2015349 | 0.86 | HTT (0.57) | MEN1KMT2ATP53HPGDSMN1; SMN2 | |
| SCHEMBL2014088 | 0.84 | LMNA (0.65) | MEN1KMT2ATP53HPGDRECQL | |
| SCHEMBL2016412 | 0.83 | TP53 (0.56) | MEN1KMT2ATP53HPGDALDH1A1 | |
| SCHEMBL12634893 | 0.83 | GRM5 (0.37) | HPGDALDH1A1RECQLSMN1; SMN2LMNA | |
| SCHEMBL17934118 | 0.82 | SCNN1A (0.44) | TP53HPGDALDH1A1POLBHTT | |
| Iodide SCHEMBL2014861 | 0.82 | GRM5 (0.37) | HPGDALDH1A1RECQLSMN1; SMN2LMNA | |
| SCHEMBL2018304 | 0.79 | HTT (0.40) | KMT2ATP53HPGDALDH1A1LMNA | |
| SCHEMBL2018051 | 0.79 | TP53 (0.45) | MEN1KMT2ATP53SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |