SCHEMBL20164274

SCHEMBL20164274

CCOC(=O)N(C)c1ccc2ccccc2c1OC(=O)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.51
ALDH1A1 P00352 3/20 0.51
LMNA P02545 2/20 0.51
NOD2 Q9HC29 1/20 0.44
NCEH1 Q6PIU2 5/20 0.41
PKM P14618 1/20 0.40
CDC25B P30305 2/20 0.40
MAPK1 P28482 2/20 0.39
KDM4E B2RXH2 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
GAA P10253 2/20 0.39
MAPT P10636 3/20 0.39
TDP1 Q9NUW8 2/20 0.39
MEN1 O00255 1/20 0.39
POLB P06746 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
THRB P10828 1/20 0.38
HCRTR1 O43613 1/20 0.38
TP53 P04637 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20164258 0.91 KMT2A (0.43) KMT2AALDH1A1LMNANOD2NCEH1
SCHEMBL20164291 0.89 NCEH1 (0.42) KMT2AALDH1A1LMNANOD2NCEH1
SCHEMBL20164251 0.88 LMNA (0.46) KMT2AALDH1A1LMNANOD2NCEH1
SCHEMBL18249382 0.81 KMT2A (0.45) KMT2AALDH1A1LMNANOD2PKM
SCHEMBL18249413 0.77 KMT2A (0.46) KMT2AALDH1A1LMNAPKMKDM4E
SCHEMBL18249438 0.77 KMT2A (0.44) KMT2AALDH1A1LMNANOD2PKM
SCHEMBL11570035 0.76 SIGMAR1 (0.56) KMT2AALDH1A1NCEH1CDC25BKDM4E
SCHEMBL15534685 0.76 ALDH1A1 (0.53) KMT2AALDH1A1LMNANOD2PKM
SCHEMBL14937495 0.75 KMT2A (0.50) KMT2AALDH1A1LMNANOD2PKM
SCHEMBL16235883 0.75 KMT2A (0.52) KMT2AALDH1A1LMNANOD2PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3298048-B1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA SRL (IT) 2019-07-03 EP disclosed
US-10221256-B2 Catalyst components for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2019-03-05 US disclosed
US-20180142044-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2018-05-24 US disclosed