SCHEMBL20164425

SCHEMBL20164425

CCC(O)CNc1nc(NC)c2nc(Cl)nc(NC)c2n1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
YTHDC1 Q96MU7 9/20 0.38
LMNA P02545 3/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
SLC29A1 Q99808 1/20 0.33
P2RY1 P47900 2/20 0.32
GAA P10253 1/20 0.32
YTHDF3 Q7Z739 2/20 0.32
YTHDF1 Q9BYJ9 2/20 0.32
YTHDF2 Q9Y5A9 2/20 0.32
CDK1 P06493 1/20 0.30
ATG4B Q9Y4P1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30560025 0.89 YTHDC1 (0.41) YTHDC1LMNASMN1; SMN2SLC29A1P2RY1
SCHEMBL20164377 0.89 YTHDC1 (0.41) YTHDC1LMNASMN1; SMN2SLC29A1P2RY1
SCHEMBL20164346 0.87 SLC29A1 (0.36) LMNASMN1; SMN2SLC29A1GAAATG4B
SCHEMBL30560041 0.85 YTHDC1 (0.40) YTHDC1LMNASMN1; SMN2P2RY1GAA
SCHEMBL20164544 0.85 YTHDC1 (0.40) YTHDC1LMNASMN1; SMN2P2RY1GAA
SCHEMBL20164329 0.85 YTHDC1 (0.40) YTHDC1LMNASMN1; SMN2P2RY1GAA
SCHEMBL20164331 0.85 YTHDC1 (0.40) YTHDC1LMNASMN1; SMN2P2RY1GAA
Hydrochloric Acid SCHEMBL20164312 0.85 SLC29A1 (0.35) LMNASMN1; SMN2SLC29A1GAAATG4B
SCHEMBL20164506 0.84 SLC29A1 (0.43) LMNASLC29A1ATG4B
SCHEMBL20179367 0.84 SLC29A1 (0.43) LMNASLC29A1ATG4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3316890-B1 NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF MAKING AND USING SAME NEURAD LTD (IL) 2023-09-06 EP disclosed
US-10294228-B2 Breathing control modulating compounds, and methods of making and using same NEURAD LTD. (IL) 2019-05-21 US disclosed
US-20180141953-A1 Novel Breathing Control Modulating Compounds, and Methods of Making and Using Same NEURAD LTD. (IL) 2018-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180141953-A1 Novel Breathing Control Modulating Compounds, and Methods of Making and Using Same MTNR1B, CHRM3, PER2 YTHDC1 2024/4885LMNA 1394/4885SMN1; SMN2 463/4885
US-10294228-B2 Breathing control modulating compounds, and methods of making and using same MTNR1B, PDE3A, CHRM3 YTHDC1 2085/4885LMNA 1200/4885SMN1; SMN2 454/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.