SCHEMBL20165779

SCHEMBL20165779

COc1c(C(C)(C)C)cc2c(c1-c1cc(C)cc(C)c1)C=C(C)C2[Si](C)(C)C1C(C)=Cc2c1cc(C(C)(C)C)c(OC)c2-c1cc(C)cc(C)c1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 2/20 0.32
PTGS1 P23219 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29874052 1.00 PTGS2 (0.32) PTGS2PTGS1
SCHEMBL25865225 0.95
SCHEMBL21433895 0.93
SCHEMBL31417743 0.92
SCHEMBL20165756 0.91 PTGS2 (0.30) PTGS2PTGS1
SCHEMBL29992354 0.91 PTGS2 (0.30) PTGS2PTGS1
SCHEMBL31355495 0.90
SCHEMBL31355497 0.90
SCHEMBL29873709 0.89 PTGS2 (0.31) PTGS2PTGS1
SCHEMBL20165789 0.89 PTGS2 (0.31) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11952481-B2 Heterophasic polypropylene composition with high flexibility and softness BOREALIS AG (AT) 2024-04-09 US disclosed
CN-111527140-B Heterophasic polypropylene composition with high flexibility and high softness 北欧化工公司 2023-11-17 CN disclosed
US-11702487-B2 Process for preparing propylene polymers BOREALIS AG (AT) 2023-07-18 US disclosed
CN-111902436-B Process for preparing propylene polymers 博里利斯股份公司 2023-06-30 CN disclosed
CN-110770264-B Process for preparing heterophasic propylene copolymers 博里利斯股份公司 2022-10-14 CN disclosed
CN-110177798-B Catalyst and process for preparing same 博里利斯股份公司 2022-08-30 CN disclosed
US-11352376-B2 Catalysts BOREALIS AG (AT) 2022-06-07 US disclosed
US-11078304-B2 Process for preparing heterophasic propylene copolymers BOREALIS AG (AT) 2021-08-03 US disclosed
US-20210230319-A1 PROCESS FOR PREPARING PROPYLENE POLYMERS BOREALIS AG (AT) 2021-07-29 US disclosed
US-20210002397-A1 PROCESS FOR PREPARING PROPYLENE COPOLYMERS COMPRISING C4-C12-APHA OLEFIN COMONOMER UNITS BOREALIS AG (AT) 2021-01-07 US disclosed
CN-111936528-A Process for preparing propylene copolymers comprising C4 to C12-alpha olefin comonomer units 博里利斯股份公司 2020-11-13 CN disclosed
CN-111902436-A Process for the preparation of propylene polymers 博里利斯股份公司 2020-11-06 CN disclosed
CN-111527140-A Heterophasic polypropylene composition with high flexibility and high softness 北欧化工公司 2020-08-11 CN disclosed
EP-3649162-A1 PROCESS FOR PREPARING HETEROPHASIC PROPYLENE COPOLYMERS Borealis AG (AT) 2020-05-13 EP disclosed
US-20200131284-A1 PROCESS FOR THE PREPARING HETEROPHASIC PROPYLENE COPOLYMERS BOREALIS AG (AT) 2020-04-30 US disclosed
CN-110770264-A Process for preparing heterophasic propylene copolymers 博里利斯股份公司 2020-02-07 CN disclosed
US-20190308995-A1 CATALYSTS BOREALIS AG (AT) 2019-10-10 US disclosed
EP-3541823-A1 CATALYSTS Borealis AG (AT) 2019-09-25 EP disclosed
WO-2019007655-A1 PROCESS FOR PREPARING HETEROPHASIC PROPYLENE COPOLYMERS BOREALIS AG (AT) 2019-01-10 WO disclosed
WO-2018091684-A1 CATALYSTS BOREALIS AG (AT) 2018-05-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11352376-B2 Catalysts SIGMAR1, H1-2, SFN PTGS2 3715/4885PTGS1 3898/4885
US-20190308995-A1 CATALYSTS SIGMAR1, H1-2, CBR1 PTGS2 3756/4885PTGS1 3935/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.