Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 7/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.52 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.52 |
| ▸ | ITK | Q08881 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.44 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21536862 | 0.88 | CHEK1 (0.58) | MAP2K4MAPK8MAPK10MAPK14MAPK1 | |
| SCHEMBL21536779 | 0.85 | PAK1 (0.61) | MAP2K4MAPK8MAPK10MAPK14MAPK1 | |
| SCHEMBL20167111 | 0.85 | MAP2K4 (0.61) | MAP2K4MAPK8MAPK10MAPK14MAPK1 | |
| SCHEMBL20167107 | 0.78 | DGAT2 (0.53) | MAPK8MAPK10MAPK14CHEK1 | |
| SCHEMBL20167110 | 0.78 | DGAT2 (0.64) | CHEK1GSK3B | |
| SCHEMBL3960972 | 0.77 | AXL (0.54) | MAP2K4MAPK8MAPK10MAPK14PAK1 | |
| SCHEMBL30364178 | 0.76 | IDO1 (0.60) | MAP2K4MAPK10MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL3966282 | 0.75 | NPBWR1 (0.55) | MAPK8MAPK10MAPK14PAK1 | |
| SCHEMBL9907662 | 0.74 | HTR5A (0.56) | — | |
| SCHEMBL5638533 | 0.74 | ITK (0.81) | MAP2K4MAPK1MAPK6MAPKAPK3ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190330239-A1 | INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2019-10-31 | — | — | US | disclosed |
| US-20190330239-A1 | INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2019-10-31 | — | — | US | disclosed |
| EP-3541374-A1 | INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | Merck Sharp & Dohme Corp. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018093696-A1 | INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190330239-A1 | INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | DGAT2, DGAT1, MOGAT2 | MAP2K4 3100/4885MAPK8 3400/4885MAPK10 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.