SCHEMBL20166477

SCHEMBL20166477

Cc1ccc([N+](=O)[O-])c(N2CCOCC2)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 14/20 0.64
ALDH1A1 P00352 9/20 0.64
SMN1; SMN2 Q16637 4/20 0.64
NPSR1 Q6W5P4 2/20 0.64
CYP2C9 P11712 6/20 0.60
LMNA P02545 4/20 0.58
HPGD P15428 2/20 0.58
L3MBTL1 Q9Y468 2/20 0.58
KDM4E B2RXH2 1/20 0.58
KMT2A Q03164 3/20 0.58
CTSB P07858 1/20 0.57
CYP2C19 P33261 5/20 0.55
CYP3A4 P08684 3/20 0.55
CYP2D6 P10635 2/20 0.55
TDP1 Q9NUW8 1/20 0.55
MEN1 O00255 2/20 0.54
PKM P14618 1/20 0.54
CYP1A2 P05177 2/20 0.53
NFKB1 P19838 1/20 0.53
HTT P42858 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL259406 0.88 MAPT (0.69) MAPTALDH1A1SMN1; SMN2CYP2C9LMNA
SCHEMBL8794400 0.86 ALDH1A1 (0.69) MAPTALDH1A1SMN1; SMN2NPSR1LMNA
SCHEMBL25891601 0.84 ALDH1A1 (0.68) MAPTALDH1A1SMN1; SMN2NPSR1CYP2C9
SCHEMBL6125268 0.83 ALDH1A1 (0.66) MAPTALDH1A1SMN1; SMN2CYP2C9LMNA
SCHEMBL5552187 0.82 MAPT (0.64) MAPTALDH1A1SMN1; SMN2LMNAL3MBTL1
SCHEMBL30699269 0.82 MAPT (0.64) MAPTALDH1A1SMN1; SMN2NPSR1CYP2C9
SCHEMBL7809569 0.82 MAPT (0.64) MAPTALDH1A1SMN1; SMN2NPSR1CYP2C9
SCHEMBL30953903 0.82 MAPT (0.64) MAPTALDH1A1SMN1; SMN2NPSR1CYP2C9
SCHEMBL5824515 0.82 MAPT (0.64) MAPTALDH1A1SMN1; SMN2NPSR1CYP2C9
SCHEMBL27038561 0.82 MAPT (0.64) MAPTALDH1A1SMN1; SMN2NPSR1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4684837-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE Temple University of the Commonwealth System of Higher Education (US) 2026-01-28 EP disclosed
US-20250282790-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE PRAEVENTIX, LLC 2025-09-11 US disclosed
EP-3541790-B1 3-(2-(4-PHENYLPIPERAZIN-1-YL)ETHYL)-2-OXA-8-AZASPIRO[4.5]DECAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS 5-HYDROXYTRYPTAMINE RECEPTOR 7 (5-HT7) MODULATORS FOR TREATING E.G. INFLAMMATORY BOWEL DISEASE, CIRCADIAN RHYTHM DISORDER OR DEPRESSION UNIV TEMPLE (US) 2025-09-03 EP disclosed
US-12338247-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2025-06-24 US disclosed
CN-119977980-A Novel modulators of 5-hydroxytryptamine receptor 7 and methods of use thereof 英联邦高等教育系统坦普尔大学 2025-05-13 CN disclosed
CN-110177776-B Novel modulators of 5-hydroxytryptamine receptor 7 and methods of use thereof 英联邦高等教育系统坦普尔大学 2025-02-28 CN disclosed
US-11760752-B2 Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors UNIVERSITY OF MARYLAND, BALTIMORE (US) 2023-09-19 US disclosed
US-20230112888-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE PRAEVENTIX, LLC 2023-04-13 US disclosed
US-11319327-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use Temple University—Of the Commonwealth System of Higher Education (US) 2022-05-03 US disclosed
US-11319327-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use Temple University—Of the Commonwealth System of Higher Education (US) 2022-05-03 US disclosed
US-20210238189-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE PRAEVENTIX, LLC 2021-08-05 US disclosed
US-20210238189-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE PRAEVENTIX, LLC 2021-08-05 US disclosed
US-10858368-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use Temple University—Of the Commonwealth System of Higher Education (US) 2020-12-08 US disclosed
US-10858368-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use Temple University—Of the Commonwealth System of Higher Education (US) 2020-12-08 US disclosed
US-20200299285-A1 CARBOXYLIC ACID, ACYL SULFONAMIDE AND ACYL SULFAMIDE-DERIVATIZED BICYCLIC AZA-HETEROAROMATICS AS SELECTIVE MCL-1 INHIBITORS AND AS DUAL MCL-1/BCL-2 INHIBITORS UNIVERSITY OF MARYLAND, BALTIMORE 2020-09-24 US disclosed
EP-3541790-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE Temple University - Of The Commonwealth System of Higher Education (US) 2019-09-25 EP disclosed
WO-2018093818-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2018-05-24 WO disclosed
WO-2018093818-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2018-05-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250282790-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE HTR7, HTR5A, HTR6 MAPT 1607/4885ALDH1A1 2885/4885SMN1; SMN2 2741/4885
US-20200299285-A1 CARBOXYLIC ACID, ACYL SULFONAMIDE AND ACYL SULFAMIDE-DERIVATIZED BICYCLIC AZA-HETEROAROMATICS AS SELECTIVE MCL-1 INHIBITORS AND AS DUAL MCL-1/BCL-2 INHIBITORS MCL1, BCLAF1, BCL2A1 MAPT 4738/4885ALDH1A1 353/4885SMN1; SMN2 1080/4885
US-11760752-B2 Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors MCL1, BCLAF1, BCL2A1 MAPT 4738/4885ALDH1A1 353/4885SMN1; SMN2 1080/4885
US-10858368-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use HTR7, HTR6, HTR5A MAPT 1443/4885ALDH1A1 2880/4885SMN1; SMN2 2544/4885
US-20230112888-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE HTR7, HTR5A, HTR6 MAPT 1607/4885ALDH1A1 2885/4885SMN1; SMN2 2741/4885
US-11319327-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use HTR7, HTR6, HTR5A MAPT 1443/4885ALDH1A1 2880/4885SMN1; SMN2 2544/4885
US-12338247-B2 Modulators of the 5-hydroxytryptamine receptor 7 and their method of use HTR7, HTR6, HTR5A MAPT 1443/4885ALDH1A1 2880/4885SMN1; SMN2 2544/4885
US-20210238189-A1 NOVEL MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE HTR7, HTR5A, HTR6 MAPT 1607/4885ALDH1A1 2885/4885SMN1; SMN2 2741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.