Sugi Predict

Sugi Predict / Compounds / SCHEMBL20168587

SCHEMBL20168587

SCHEMBL20168587

CC(=O)ONC(=O)CCC(Cc1ccc(C(=O)O)cc1)C(=O)OC(C)(C)C

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ FOLH1 Q04609 6/20 0.50
▸ LTA4H P09960 1/20 0.37
▸ CA2 P00918 1/20 0.36
▸ CA9 Q16790 1/20 0.36
▸ ANPEP P15144 1/20 0.36
▸ ENPEP Q07075 1/20 0.36
▸ ACACB O00763 1/20 0.36
▸ KMT2A Q03164 1/20 0.35
▸ SLC7A5 Q01650 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ ITGA4 P13612 1/20 0.34
▸ ITGB7 P26010 1/20 0.34
▸ ACE P12821 1/20 0.34
▸ MMP1 P03956 1/20 0.34
▸ MMP3 P08254 1/20 0.34
▸ MMP9 P14780 1/20 0.34
▸ PPARG P37231 1/20 0.33
▸ PPARD Q03181 1/20 0.33
▸ PPARA Q07869 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20179259 0.91 FOLH1 (0.39) FOLH1LTA4HCA2CA9SLC7A5
SCHEMBL20168728 0.88 HTT (0.41) FOLH1CA2CA9MAPTPPARG
SCHEMBL20168380 0.88 FOLH1 (0.47) FOLH1LTA4HCA2CA9ANPEP
SCHEMBL21570576 0.87 FOLH1 (0.53) FOLH1LTA4HANPEPENPEPSLC7A5
Benzene SCHEMBL20168308 0.87 FOLH1 (0.53) FOLH1LTA4HANPEPENPEPSLC7A5
SCHEMBL20168753 0.87 CYP4F2 (0.40) FOLH1LTA4HCA2CA9
SCHEMBL20168738 0.86 FOLH1 (0.46) FOLH1LTA4HCA2CA9ANPEP
SCHEMBL20168672 0.86 FOLH1 (0.68) FOLH1
SCHEMBL20179172 0.86 FOLH1 (0.67) FOLH1ANPEPENPEPACACBKMT2A
SCHEMBL20168291 0.85 FOLH1 (0.50) FOLH1LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866394-B2 Prodrugs of hydroxamate-based GCPII inhibitors THE JOHNS HOPKINS UNIVERSTY (US) 2024-01-09 — — US disclosed
US-20210355079-A1 PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I. (CZ) 2021-11-18 — — US disclosed
US-11059775-B2 Prodrug compositions and utility of hydroxamate-based GCPII inhibitors THE JOHNS HOPKINS UNIVERSITY (US) 2021-07-13 — — US disclosed
US-20190352255-A1 NOVEL PRODRUG COMPOSITIONS AND UTILITY OF HYDROXAMATE-BASED GCPII INHIBITORS THE JOHNS HOPKINS UNIVERSITY 2019-11-21 — — US disclosed
WO-2018094334-A1 PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS THE JOHNS HOPKINS UNIVERSITY (US) 2018-05-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190352255-A1 NOVEL PRODRUG COMPOSITIONS AND UTILITY OF HYDROXAMATE-BASED GCPII INHIBITORS GPI, TPI1, HPGDS FOLH1 10/4885LTA4H 1303/4885CA2 828/4885
US-20210355079-A1 PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS TPI1, HPGDS, GPI FOLH1 39/4885LTA4H 1571/4885CA2 918/4885
US-11059775-B2 Prodrug compositions and utility of hydroxamate-based GCPII inhibitors GLS, HPGDS, GPI FOLH1 15/4885LTA4H 1594/4885CA2 779/4885
US-11866394-B2 Prodrugs of hydroxamate-based GCPII inhibitors TPI1, HPGDS, GPI FOLH1 39/4885LTA4H 1571/4885CA2 918/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.