Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 2/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2525779 | 0.83 | KEAP1 (0.31) | KEAP1NFE2L2 | |
| SCHEMBL10358243 | 0.80 | KEAP1 (0.36) | KEAP1NFE2L2ALDH1A1CYP2D6TSHR | |
| SCHEMBL31352036 | 0.79 | ALDH1A1 (0.36) | KEAP1NFE2L2ALDH1A1CYP2D6TSHR | |
| SCHEMBL2579739 | 0.79 | ALDH1A1 (0.36) | KEAP1NFE2L2ALDH1A1CYP2D6TSHR | |
| SCHEMBL11365788 | 0.78 | CYP2C19 (0.38) | ALDH1A1CYP2D6TSHRCYP2C19HIF1A | |
| SCHEMBL8131339 | 0.77 | KEAP1 (0.37) | KEAP1NFE2L2ALDH1A1CYP2D6TSHR | |
| SCHEMBL9129355 | 0.77 | ALDH1A1 (0.35) | KEAP1NFE2L2ALDH1A1CYP2D6TSHR | |
| SCHEMBL8735978 | 0.77 | KEAP1 (0.37) | KEAP1NFE2L2ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL29142969 | 0.77 | KEAP1 (0.37) | KEAP1NFE2L2ALDH1A1CYP2D6TSHR | |
| SCHEMBL28107685 | 0.77 | CYP2D6 (0.41) | KEAP1NFE2L2ALDH1A1CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110472-A1 | BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND HER2, AND METHODS OF USE THEREOF | Regeneron Pharmaceuticals, Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| EP-3541842-A1 | ANTI-MET ANTIBODIES, BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND MET, AND METHODS OF USE THEREOF | Regeneron Pharmaceuticals, Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018093866-A1 | ANTI-MET ANTIBODIES, BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND MET, AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2018-05-24 | — | — | WO | disclosed |