Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69968 | 0.73 | KIF11 (0.36) | LTB4RLTB4R2TRPA1PTGS1CACNA1C | |
| SCHEMBL19432962 | 0.69 | TP53 (0.48) | — | |
| SCHEMBL19751469 | 0.64 | LTB4R (0.39) | LTB4RLTB4R2PTGS1KIF11 | |
| SCHEMBL19751549 | 0.64 | BRD4 (0.36) | LTB4RLTB4R2KIF11 | |
| SCHEMBL23712389 | 0.63 | KIF11 (0.40) | LTB4RLTB4R2KIF11 | |
| SCHEMBL23775721 | 0.63 | HPGD (0.33) | LTB4RLTB4R2KIF11 | |
| SCHEMBL27344507 | 0.62 | ALOX5 (0.41) | TRPA1PTGS1CACNA1CKIF11 | |
| SCHEMBL30811604 | 0.62 | ALOX5 (0.41) | TRPA1PTGS1CACNA1CKIF11 | |
| SCHEMBL5714522 | 0.62 | TRPA1 (0.34) | TRPA1PTGS1CACNA1CKIF11 | |
| SCHEMBL23775581 | 0.61 | TRPA1 (0.34) | TRPA1PTGS1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975902-B2 | Compounds for the inhibition of cyclophilins and uses thereof | MERCK PATENT GMBH (DE) | 2018-05-22 | — | — | US | disclosed |