SCHEMBL20169801

SCHEMBL20169801

O=c1c(OCc2ccccc2)c(-c2ccc(OCc3ccccc3)cc2)oc2cc(OCc3ccccc3)ccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 5/20 0.59
MAOB P27338 6/20 0.58
ACHE P22303 1/20 0.57
KDM4E B2RXH2 1/20 0.57
MEN1 O00255 1/20 0.57
ALDH1A1 P00352 1/20 0.57
CYP3A4 P08684 1/20 0.57
MAPT P10636 1/20 0.57
THRB P10828 1/20 0.57
HPGD P15428 1/20 0.57
KMT2A Q03164 1/20 0.57
HSD17B10 Q99714 1/20 0.57
PPARG P37231 1/20 0.56
MAOA P21397 2/20 0.56
TDP1 Q9NUW8 2/20 0.56
NPC1 O15118 1/20 0.56
CASP3 P42574 1/20 0.56
RAB9A P51151 1/20 0.56
SENP8 Q96LD8 1/20 0.56
SENP7 Q9BQF6 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28565701 0.91 ABCG2 (0.69) ABCG2KDM4EALDH1A1MAPTHPGD
SCHEMBL17523228 0.91 ABCG2 (0.58) ABCG2MAOBACHEKDM4EMEN1
SCHEMBL117674 0.87 MAOB (0.50) ABCG2MAOBACHEPPARGMAOA
SCHEMBL20169884 0.87 CYP3A4 (0.61) ABCG2MAOBACHEKDM4EMEN1
SCHEMBL31031156 0.84 AR (0.59) ABCG2MAOBACHEPPARGAR
SCHEMBL5320049 0.83 ADRB2 (0.52) ABCG2MAOBACHEKDM4EMEN1
SCHEMBL4150944 0.83 MAOB (0.51) ABCG2MAOBACHEMAPTPPARG
SCHEMBL972002 0.83 KDM4E (0.68) ABCG2KDM4EMEN1ALDH1A1CYP3A4
SCHEMBL10769734 0.83 ABCG2 (0.72) ABCG2KDM4EMEN1ALDH1A1CYP3A4
SCHEMBL27491848 0.83 KDM4E (0.66) MAOBACHEKDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2981260-B1 NOVEL ANALOGUES OF EPICATECHIN AND RELATED POLYPHENOLS SPHAERA PHARMA PRIVATE LTD (IN) 2021-01-13 EP disclosed
US-9975869-B2 Analogues of epicatechin and related polyphenols SPHAERA PHARMA PVT. LTD. (IN) 2018-05-22 US disclosed