Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170705 | 0.73 | OPRM1 (0.36) | OPRK1OPRM1OPRD1MRGPRX2MAPT | |
| SCHEMBL20170727 | 0.69 | OPRM1 (0.64) | OPRK1OPRM1OPRD1SIGMAR1MRGPRX2 | |
| SCHEMBL20170638 | 0.69 | OPRM1 (0.64) | OPRK1OPRM1OPRD1SIGMAR1MRGPRX2 | |
| SCHEMBL20170778 | 0.67 | HCRTR1 (0.33) | HCRTR1OPRK1OPRM1OPRD1 | |
| SCHEMBL20170724 | 0.66 | OPRM1 (0.62) | OPRK1OPRM1OPRD1SIGMAR1MRGPRX2 | |
| SCHEMBL13972295 | 0.66 | HCRTR1 (0.41) | HCRTR1HTR1AOPRK1OPRM1OPRD1 | |
| SCHEMBL13972294 | 0.66 | HCRTR1 (0.41) | HCRTR1HTR1AOPRK1OPRM1OPRD1 | |
| SCHEMBL18473438 | 0.66 | HCRTR1 (0.41) | HCRTR1HTR1AOPRK1OPRM1OPRD1 | |
| SCHEMBL20852459 | 0.65 | HTR1A (0.41) | HCRTR1HTR1A | |
| SCHEMBL20170848 | 0.65 | OPRM1 (0.42) | HCRTR1HTR1AOPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |