Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170761 | 0.83 | OPRM1 (0.34) | OPRM1OPRD1OPRK1MRGPRX2MAPT | |
| SCHEMBL20170781 | 0.79 | OPRM1 (0.33) | OPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL20170607 | 0.75 | OPRM1 (0.37) | OPRM1 | |
| SCHEMBL20170728 | 0.75 | OPRM1 (0.37) | OPRM1 | |
| SCHEMBL20170652 | 0.75 | OPRM1 (0.37) | OPRM1 | |
| SCHEMBL20170641 | 0.74 | ADRA1A (0.34) | OPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL20170669 | 0.74 | ADRA1A (0.34) | OPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL20170645 | 0.73 | OPRM1 (0.39) | OPRM1OPRD1OPRK1MRGPRX2MAPT | |
| SCHEMBL20170697 | 0.73 | HTR1A (0.34) | OPRM1 | |
| SCHEMBL20170640 | 0.73 | HTR1A (0.34) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |