Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170718 | 0.84 | GAA (0.36) | GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL12945025 | 0.76 | GAA (0.38) | GAAMEN1ALDH1A1PKMKMT2A | |
| SCHEMBL20170666 | 0.75 | GAA (0.37) | GAAMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL20170821 | 0.74 | GAA (0.36) | GAA | |
| SCHEMBL22058862 | 0.73 | GAA (0.35) | GAAMEN1ALDH1A1PKMKMT2A | |
| SCHEMBL20170840 | 0.71 | GAA (0.41) | GAAALDH1A1ERN1TSHRSMN1; SMN2 | |
| SCHEMBL20170711 | 0.69 | GAA (0.39) | GAA | |
| SCHEMBL18458095 | 0.68 | GAA (0.45) | GAAMEN1ALDH1A1PKMKMT2A | |
| SCHEMBL10222587 | 0.68 | GAA (0.39) | GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL20170701 | 0.68 | GAA (0.39) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |