Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170666 | 0.81 | GAA (0.37) | GAAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20170664 | 0.75 | GAA (0.36) | GAASMN1; SMN2 | |
| SCHEMBL20170821 | 0.75 | GAA (0.36) | GAAOPRM1 | |
| SCHEMBL10222587 | 0.74 | GAA (0.39) | GAAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20170771 | 0.74 | OPRM1 (0.40) | OPRM1OPRD1OPRK1 | |
| SCHEMBL22058068 | 0.72 | GAA (0.35) | GAAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20170840 | 0.72 | GAA (0.41) | GAAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20170711 | 0.70 | GAA (0.39) | GAAOPRM1OPRD1OPRK1 | |
| SCHEMBL20170701 | 0.69 | GAA (0.39) | GAA | |
| SCHEMBL12945025 | 0.68 | GAA (0.38) | GAAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |