Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29165705 | 0.73 | OPRD1 (0.45) | OPRD1GAAPIN1MAPTCYP3A4 | |
| SCHEMBL12646364 | 0.63 | OPRM1 (0.51) | OPRD1GAAMAPTCYP3A4KDM4E | |
| SCHEMBL18457626 | 0.63 | OPRM1 (0.51) | OPRD1GAAMAPTCYP3A4KDM4E | |
| SCHEMBL22058062 | 0.63 | OPRM1 (0.51) | OPRD1GAAMAPTCYP3A4KDM4E | |
| SCHEMBL29620334 | 0.63 | OPRM1 (0.51) | OPRD1GAAMAPTCYP3A4KDM4E | |
| SCHEMBL12960787 | 0.63 | OPRM1 (0.51) | OPRD1GAAMAPTCYP3A4KDM4E | |
| SCHEMBL22058058 | 0.63 | OPRM1 (0.51) | OPRD1GAAMAPTCYP3A4KDM4E | |
| SCHEMBL18973514 | 0.62 | OPRM1 (0.53) | OPRD1CYP3A4ALDH1A1LMNAHSD17B10 | |
| SCHEMBL4655427 | 0.60 | CD274 (0.36) | OPRD1PIN1MAPTCYP3A4ALDH1A1 | |
| SCHEMBL21422738 | 0.60 | ACHE (0.50) | OPRD1GAAMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |