Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17263289 | 0.86 | JAK3 (0.46) | HSP90AB1LMNACRHR1JAK3RAB9A | |
| SCHEMBL13320968 | 0.80 | CYP1A2 (0.42) | CRHR1PDE10AKDM4E | |
| SCHEMBL17263292 | 0.80 | CRHR1 (0.44) | CRHR1DRD1RAB9ANPC1MEN1 | |
| SCHEMBL11985667 | 0.80 | CRHR1 (0.38) | CRHR1JAK3DRD1RAB9ANPC1 | |
| SCHEMBL17263291 | 0.79 | CCNB2 (0.39) | LMNAJAK3RAB9ANPC1MEN1 | |
| SCHEMBL26155339 | 0.76 | CYP1A2 (0.45) | HSP90AB1LMNACRHR1RAB9ANPC1 | |
| SCHEMBL17263278 | 0.76 | HSP90AB1 (0.39) | HSP90AB1LMNACRHR1RAB9ANPC1 | |
| SCHEMBL18356854 | 0.73 | CNR2 (0.44) | HSP90AB1LMNACRHR1RAB9ANPC1 | |
| SCHEMBL15256080 | 0.73 | NPC1 (0.40) | LMNARAB9ANPC1MEN1KMT2A | |
| SCHEMBL11438697 | 0.72 | DRD1 (0.39) | HSP90AB1CRHR1DRD1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323821-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | Pfizer Inc (US) | 2018-05-23 | — | — | EP | disclosed |