Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.57 |
| ▸ | NPC1 | O15118 | 8/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | CASP3 | P42574 | 2/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.49 |
| ▸ | WNT1 | P04628 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19002383 | 0.83 | HDAC3 (0.47) | RAB9ANPC1MAPTCASP3SENP7 | |
| SCHEMBL20172431 | 0.74 | RAB9A (0.52) | RAB9ANPC1ALDH1A1NAMPTSMN1; SMN2 | |
| SCHEMBL30844256 | 0.72 | LMNA (0.58) | RAB9ANPC1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL13647207 | 0.72 | LMNA (0.58) | RAB9ANPC1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL19002385 | 0.72 | GPR142 (0.48) | MAPTPOLB | |
| SCHEMBL28615866 | 0.71 | RAB9A (0.73) | RAB9ANPC1MAPTCASP3SENP7 | |
| SCHEMBL2888926 | 0.70 | HCAR3 (0.51) | TP53 | |
| SCHEMBL20665563 | 0.70 | HCAR3 (0.37) | RAB9ANPC1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL19111004 | 0.70 | EPHX2 (0.70) | ALDH1A1MAPK1POLBSMN1; SMN2PKM | |
| SCHEMBL6783579 | 0.69 | RAB9A (1.00) | RAB9ANPC1MAPK1POLBNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137459-B1 | MORPHOLIN-PYRIDINE DERIVATIVES HAVING AFFINITY TO THE TAAR1 RECEPTOR | HOFFMANN LA ROCHE (CH) | 2018-05-23 | — | — | EP | disclosed |