Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 12/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27345694 | 0.81 | NOTUM (0.38) | NOTUMHSD17B3CYP2D6CYP2C9LMNA | |
| SCHEMBL64071 | 0.79 | NOTUM (0.43) | NOTUMHSD17B3CYP2D6CYP2C9POLB | |
| SCHEMBL28001295 | 0.78 | LMNA (0.35) | LMNA | |
| SCHEMBL12254228 | 0.76 | MEN1 (0.39) | CYP2D6CYP2C9LMNAGLA | |
| SCHEMBL4728242 | 0.75 | — | — | |
| SCHEMBL14269349 | 0.73 | ALDH1A1 (0.40) | POLB | |
| SCHEMBL185461 | 0.71 | — | — | |
| SCHEMBL641600 | 0.70 | LMNA (0.52) | NOTUMCYP2D6CYP2C9LMNAPOLB | |
| SCHEMBL11174570 | 0.70 | NOTUM (0.37) | NOTUMHSD17B3CYP2D6CYP2C9POLB | |
| SCHEMBL887169 | 0.69 | NOTUM (0.42) | NOTUMCYP2D6CYP2C9POLBGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180140600-A1 | DEUTERATED DEHYDROPHENYLAHISTIN COMPOUNDS AND PREPARATION METHOD THEREOF AND USE THEREOF IN PREPARATION OF ANTI-TUMOR DRUGS | SHENZHEN HUAHONG MARINE BIOMEDICINE CO., LTD (CN) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180140600-A1 | DEUTERATED DEHYDROPHENYLAHISTIN COMPOUNDS AND PREPARATION METHOD THEREOF AND USE THEREOF IN PREPARATION OF ANTI-TUMOR DRUGS | DHPS, DHODH, DHFR | NOTUM 2842/4885HSD17B3 82/4885CYP2D6 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.