SCHEMBL20173622

SCHEMBL20173622

CN(c1ccc(C#N)cc1)c1ccc([Si](C)(C)C)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.42
CYP2A6 P11509 2/20 0.40
ALDH1A1 P00352 2/20 0.40
KDM4C Q9H3R0 1/20 0.37
CA12 O43570 1/20 0.35
CA2 P00918 1/20 0.35
CA3 P07451 1/20 0.35
CA6 P23280 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
NR1H3 Q13133 1/20 0.35
APP P05067 2/20 0.35
LOXL2 Q9Y4K0 1/20 0.34
KDM4E B2RXH2 1/20 0.34
LMNA P02545 1/20 0.34
GAA P10253 1/20 0.34
NOTUM Q6P988 1/20 0.34
SCN9A Q15858 1/20 0.34
KIF11 P52732 2/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8550513 0.85 CYP2A6 (0.52) ABCG2CYP2A6ALDH1A1KDM4CCA12
SCHEMBL1161032 0.85 CYP2A6 (0.52) CYP2A6ALDH1A1CA12CA2CA3
SCHEMBL13098205 0.83 TSHR (0.38) ALDH1A1NR1H3APPTSHR
SCHEMBL29027300 0.79 MMP3 (0.52) CYP2A6ALDH1A1CA12CA2CA3
SCHEMBL20800876 0.78 ALDH1A1 (0.70) ABCG2CYP2A6ALDH1A1KDM4CCA12
SCHEMBL149439 0.78 TSHR (0.54) ABCG2CYP2A6ALDH1A1CA12CA2
SCHEMBL15223251 0.78 ALDH1A1 (0.40) CYP2A6ALDH1A1NR1H3KDM4ELMNA
SCHEMBL1705387 0.78 GAA (0.39) ALDH1A1CA2NR1H3GAACHRNB2
SCHEMBL15223245 0.78 ALDH1A1 (0.40) CYP2A6ALDH1A1NR1H3KDM4ELMNA
SCHEMBL20173613 0.76 KDM4E (0.48) ABCG2CYP2A6ALDH1A1CA12CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10651411-B2 Compound and organic light emitting device containing same LG CHEM, LTD. (KR) 2020-05-12 US disclosed
US-20180145272-A1 COMPOUND AND ORGANIC LIGHT EMITTING DEVICE CONTAINING SAME LG CHEM, LTD. (KR) 2018-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180145272-A1 COMPOUND AND ORGANIC LIGHT EMITTING DEVICE CONTAINING SAME CRY1, CRY2, OR10J3 ABCG2 2972/4885CYP2A6 499/4885ALDH1A1 87/4885
US-10651411-B2 Compound and organic light emitting device containing same CRY1, CRY2, OR10J3 ABCG2 2972/4885CYP2A6 499/4885ALDH1A1 87/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.